Endocrine Abstracts

Background: Abdominal fat accumulation is a risk factor for type 2 diabetes and cardiovascular disease, whereas lower body fat is protective. Erythroferrone (ERFE) is a recently discovered protein that increases intestinal iron absorption by inhibiting hepcidin. ERFE has been shown to inhibit BMP2 signalling and work from our group has shown that BMP2 is a differentiation factor for subcutaneous abdominal, but not gluteal, adipocytes. Because of this, we hypothesised that ERFE...

Aims: Body composition is associated with bone mineral density, but the precise associations between body fat distribution and bone mineral density (BMD) remain unclear. We hypothesised that the regional adipose tissue depots would have independent associations with BMD.Methods: We used data from 4900 healthy individuals aged 30–50 years old from the Oxford Biobank to analyse associations between regional fat mass and lean mass with total BMD.<p...

Background: Type III hyperlipidaemia (T3HL) is characterised by equimolar increases in plasma triglyceride and cholesterol on an APOE2/2 genotype background and conveys a high risk of early-onset cardiovascular disease (CVD). Phenotypic penetrance of T3HL is <10% and precipitated by several endocrine/metabolic disorders such as obesity, diabetes and hypothyroidism. We explored the effect of triglyceride-raising polygenic score precipitating T3HL, in the context of...